By David E. Schteingart (auth.), Gary D. Hammer, Tobias Else (eds.)
This first version of the textbook “Adrenocortical Carcinoma: simple Sciences and scientific options” presents a concise compilation of suitable information advancing our present figuring out of this infrequent melanoma. Chapters are devoted to numerous points of either the fundamental biology and the scientific technological know-how on the subject of adrenocortical carcinoma (ACC). specialist clinicians introduce the reader to present state of the art scientific care of sufferers with ACC. As a substantial physique of information on ACC has accrued over the past many years, specialist scientists have authored extra sections that function a reference resource for the skilled researcher in addition to an creation for the trainee within the laboratory or health facility. medical subject matters span the epidemiology, analysis and remedy of ACC. clinical subject matters components span the pathology and pathophysiology of ACC with a unique specialize in experimental types of adrenocortical tumors and up to date advances within the genetic features and signaling pathways in ACC. The content material of this e-book used to be compiled and edited with the purpose of facilitating the interpretation of information into destiny diagnostic and healing instruments that may eventually increase sufferer care.
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Extra info for Adrenocortical Carcinoma: Basic Science and Clinical Concepts
Clin Endocrinol (Oxf) 60:273–287 21. Seccia TM et al (2005) Aldosterone-producing adrenocortical carcinoma: an unusual cause of Conn’s syndrome with an ominous clinical course. Endocr Relat Cancer 12(1):149–159 22. Barzon L et al (2005) Shift from Conn’s syndrome to Cushing’s syndrome in a recurrent adrenocortical carcinoma. Eur J Endocrinol 153(5):629–636 23. Hisamatsu H et al (2002) Adrenocortical carcinoma with primary aldosteronism associated with Cushing syndrome during recurrence. BJU Int 90(9):971–972 24.
The increased risk for male smokers was also seen in another series in 250,000 US veterans . Furthermore, a small study in rats described three ACCs in 80 rats that were exposed to chronic tobacco inhalation in comparison to none in 93 controls . Nevertheless, these epidemiological studies have to be assessed with caution, because in none of the cases ACC was confirmed by histological reports and in some patients adrenal metastases of lung cancer may have been misdiagnosed as ACC. Accordingly, a recent review on tobacco use and cancer 3 Epidemiology of Adrenocortical Carcinoma 25 causation judged the available evidence for an association of smoking and ACC as too weak to draw firm conclusions .
24-h urinary-free cortisol, midnight salivary or serum cortisol, ACTH, CRH-test). All patients with proven or suspected cortisol excess need perioperative coverage with hydrocortisone. 4 Clinical Presentation and Initial Diagnosis 37 Aldosterone-secreting ACCs are rare and usually present with severe hypokalemia and high serum aldosterone concentration. In the German ACC Registry, co-secretion of other steroids has been documented in 24 of 37 patients with aldosterone-producing tumors. Therefore, purely aldosterone-secreting adrenal tumors <4 cm are suggestive of a benign adenoma.
Adrenocortical Carcinoma: Basic Science and Clinical Concepts by David E. Schteingart (auth.), Gary D. Hammer, Tobias Else (eds.)