By Jose M. Palacios, Angel Pazos, Daniel Hoyer (auth.), Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo (eds.)

ISBN-10: 1607619407

ISBN-13: 9781607619406

ISBN-10: 1607619415

ISBN-13: 9781607619413

Research of 5-HT2c receptors stretches again twenty-five years, and whereas a lot of it's been efficient, the previous decade of study has been outstanding by way of either volume produced and insights won. it's rarely stunning that 5-HT2c receptor learn has grown so fruitful, provided that it's a renowned critical serotonin receptor subtype greatly expressed in the significant and the peripheral fearful process and is assumed to play an incredible position within the legislation of diverse behaviors. It has additional been proven by means of experimental and scientific statement that it can signify a potential healing goal for the improvement of substances for quite a number important anxious procedure issues. The time, as a result, is greater than applicable to supply the 1st ever review of the study of 5-HT2c receptors. a part of the preferred and critical sequence, “The Receptors,” The 5-HT2c Receptor presents a radical replace of the useful prestige of the 5-HT2c receptor. It covers the molecular, mobile, anatomical, biochemical and behavioral facets of this receptor as a way to spotlight its particular regulatory houses and the rising sensible value of constitutive job and RNA-editing in vivo. furthermore, the publication investigates the receptors’ healing strength in various varied illnesses, handled separately in separate chapters, together with melancholy, drug abuse, schizophrenia, consuming issues, Parkinson’s disorder, Prader-Willi Syndrome, Alzheimer’s disorder and epilepsy. whereas now not exhaustive, this article is a crucial device in realizing the prior and encouraging the way forward for interdisciplinary examine at the 5-HT2c receptor.

Show description

Read Online or Download 5-HT2C Receptors in the Pathophysiology of CNS Disease PDF

Similar mathematicsematical physics books

Download e-book for iPad: Clinical Electrophysiology: A Handbook for Neurologists by Peter W. Kaplan

Bridging the scientific electrophysiological research with the neurological consultationAcutely ailing sufferers current with indicators that don’t instantly yield a prognosis. Electrophysiological checking out can aid prognosis yet provided that the correct assessments are ordered.  they have to be adequately interpreted at the side of the particular signs.

Download e-book for iPad: Tetraplegia & Paraplegia: A Guide for Physiotherapists 5th by Ida Bromley MBE FCSP

The fifth version of this well-established, useful textbook specializes in dealing with and rehabilitating tetraplegic and paraplegic sufferers. This version displays the circulate of care of those sufferers to the neighborhood and non-specialist devices, and fresh alterations in laws. Generously illustrated with transparent line drawings, it info the most recent relocating and dealing with suggestions with step by step sequences.

Get Quantum versus Chaos : Questions Emerging from Mesoscopic PDF

Quantum and chaos, key innovations in modern technology, are incompatible through nature. This quantity provides an research into quantum delivery in mesoscopic or nanoscale structures that are classically chaotic and indicates the luck and failure of quantal, semiclassical, and random matrix theories in facing questions rising from the mesoscopic cosmos.

New PDF release: Scientific Detectors for Astronomy: The Beginning of a New

Those complaints are from the 5th workshop of a sequence that targeting optical CCDs for the 1st 4 installments. At this workshop, for the 1st time, our "bandpass" used to be broadened to incorporate infrared detectors. each best producer, all significant astronomical observatories and the specialists within the box accrued at the great Island of Hawaii for every week lengthy workshop devoted to clinical detectors for astronomy.

Extra resources for 5-HT2C Receptors in the Pathophysiology of CNS Disease

Example text

Autoradiographic mapping of serotonin-1 receptors. Neuroscience 21:97–122. Pompeiano M, Palacios JM, Mengod G (1994) Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res Mol Brain Res 23:163–178. Porras G, Di Matteo V, Fracasso C, et al (2002) 5-HT2A and 5-HT2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both rat nucleus accumbens and striatum. Neuropsychopharmacology 26:311–324. Prichett DB, Bach AWJ, Wozny M, et al (1988) Structure and functional expression of cloned rat serotonin 5-HT2 receptor.

Br J Pharmacol 149:861–869. Cassel JC, Jeltsch H (1995) Serotonergic modulation of cholinergic function in the central nervous system: cognitive implications. Neuroscience 69:1–41. Clemett DA, Punhani T, Duxon MS, Blackburn TP, Fone KCF (2000) Immunohistochemical localisation of the 5-HT2C receptor protein in the rat CNS. Neuropharmacology 39:123–132. De Deurwaerdère P, Navailles S, Berg KA, Clarke WP, Spampinato U (2004) Constitutive activity of serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens.

1, Structure II). 8) (Bromidge et al. 1999). Although indolines 2, 10, and 15 displayed high affinity and specificity for the 5-HT2C receptor, they potently inhibited a number of human cytochrome P450 enzymes, in particular, the CYP1A2 isoform, and this precluded further development. Introduction of steric hindrance around the pyridine nitrogen of 10 revealed 3 The Medicinal Chemistry of 5-HT2C Receptor Ligands 33 that the unhindered nitrogen was responsible for the P450 inhibitory activity. Modeling studies revealed that the lipophilic pocket that was occupied by the pyridine ring was quite deep.

Download PDF sample

5-HT2C Receptors in the Pathophysiology of CNS Disease by Jose M. Palacios, Angel Pazos, Daniel Hoyer (auth.), Giuseppe Di Giovanni, Ennio Esposito, Vincenzo Di Matteo (eds.)

by Christopher

Rated 4.40 of 5 – based on 9 votes