By Ramana S. Moorthy MD
Starts with an in-depth evaluate of immunemedicated eye sickness, summarizing easy immunologic options, ocular immune responses and specified subject matters in ocular immunology. Discusses the medical method of uveitis and studies noninfectious (autoimmune) and infectious different types of uveitis, with an extended part on viral uveitis and new fabric on infectious and noninfectious scleritis. stronger detection of infectious brokers through immunologic and genetic tools and new biologic therapeutics are distinct. additionally covers endophthalmitis, masquerade syndromes, problems of uveitis and ocular points of AIDS. encompasses a variety of new colour photographs. significant revision 2011-2012
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Extra resources for 2011-2012 Basic and Clinical Science Course, Section 9: Intraocular Inflammation and Uveitis (Basic & Clinical Science Course)
Another subset, T helper-2 (Th2), secretes 40 • Intraocular Inflammation and Uveitis Immune processing CDS ----_ _ B lymphocyte T lymphocytes IgM IgG 1 or 3 Complement, ADCC - . CD4 Regulator Cytokines synthesized: Functions: T lymphocytes or DH T lymphocytes IgE IgA Allergen Secretory T lymphocytes Helper TGF -~ Others Down-regulates helper IgG4 Agglutinize Lymph node Th2 Cytokines synthesized: Cytokines synthesized: IL-2 IFN-y IL-4 IL-S IL-10 TNF -~ IL-12 Functions: Functions: Inhibits Th2 Inhibits Thl Helps IgE, IgA Helps IgG 1, IgG3 Figure 2-4 Helper Thl Schematic illustratio n of immu'ne processing of antigen w ithin the lymph node.
T regulatory (Treg) cells form another subset of helper T cells; they are identified not by their cytokine profile but by the simulta neous surface expression ofCD4, CD2S, and Foxp3. Treg cells are essentiall y suppressor-type T cells that down -regulate other T cell populations. Treg cells appear to be generated in the thymus in d evelop me nt and are essential to self-tole rance, the process by which auto reactive T cells are minimized and their function down- regulated. These subsets are important because the different cytokines produced by different cell typ es profoundly influence subsequent "downstream" immune processing, B-Iymp hocyte CHAPTER 2: Immunization and Adaptive Immunity.
Completion of B-Iymphocyte activation requires further interaction with helper T lymphocytes, which release cytokines, inducing B lymphocytes to undergo cell division and to increase production of antibodies, thus releasing antitoxin antibodies into the lymph fluid and ultimately the venous circulation. The effector phase begins when the primed T lymphocytes, primed B lymphocytes, or antibodies leave the lymphatics and enter the peripheral site of the original antigen encounter. By 5-7 days after exposure, much of the urushiol toxin might have already been removed through nonspecific clearance mechanisms such as desquamation of exposed epidermis or washing of involved skin.
2011-2012 Basic and Clinical Science Course, Section 9: Intraocular Inflammation and Uveitis (Basic & Clinical Science Course) by Ramana S. Moorthy MD